Mycophenolate mofetil in neuropsychiatric systemic lupus erythematosus
نویسندگان
چکیده
منابع مشابه
Mycophenolate mofetil in neuropsychiatric systemic lupus erythematosus.
Neuropsychiatric abnormalities frequently occur in patients with systemic lupus erythematosus, affecting as many as 14-75% of people with this disease. High-dose steroid with or without anticoagulation is the mainstay of treatment in neuropsychiatric systemic lupus erythematosus (NPSLE). Use of mycophenolate as a steroid sparing drug may be a potential alternative agent in the therapy of NPLE, ...
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PURPOSE OF REVIEW Clinicians are increasingly using mycophenolate mofetil (MMF) for the treatment of systemic lupus erythematosus (SLE). This review will discuss the key studies that have contributed to our understanding of the efficacy and safety of MMF in the treatment of SLE. RECENT FINDINGS The Aspreva Lupus Management Study (ALMS) firmly established that MMF is equivalent to intravenous ...
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Neuropsychiatric systemic lupus erythematosus (NPSLE) is the least understood, yet perhaps the most prevalent manifestation of lupus. The pathogenesis of NPSLE is multifactorial and involves various inflammatory cytokines, autoantibodies, and immune complexes resulting in vasculopathic, cytotoxic and autoantibody-mediated neuronal injury. The management of NPSLE is multimodal and has not been s...
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ژورنال
عنوان ژورنال: Indian Journal of Medical Sciences
سال: 2005
ISSN: 0019-5359
DOI: 10.4103/0019-5359.16652